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. Author manuscript; available in PMC: 2016 Feb 26.
Published in final edited form as: Cell. 2015 Feb 19;160(5):829–841. doi: 10.1016/j.cell.2015.01.033

Figure 2. Ghrelin rapidly modulates AgRP and POMC neurons.

Figure 2

(A and C) Recordings from a mouse expressing GCaMP6s in AgRP or POMC neurons that was challenged with injection of ghrelin (light gray) followed by presentation of a pellet of chow (dark gray). (B and D). Calcium signals from AgRP and POMC neurons aligned to the time of PBS or ghrelin injection, or chow presentation to ghrelin treated mice. Red and gray indicate the mean response and standard error (AgRP, n=7; POMC, n=5). In each trial fluorescence was normalized by assigning a value of 1.0 to the median value of data points within a two minute window at −5 min before treatment. (E) Peri-event plots showing the response from a single trial of five AgRP mice and five POMC mice.