Table 2.
Adjusted Odds Ratios (95% Confidence Intervals) of elevated hs-troponin T and elevated NT-proBNP by quartiles of liver enzymes
| Model 1 OR (95% CI) |
Model 2 OR (95% CI) |
Model 3 OR (95% CI) |
|
|---|---|---|---|
|
Elevated hs-troponin T (>14 ng/L)
| |||
| ALT | |||
| Q1 | 1 (Reference) | 1 (Reference) | 1 (Reference) |
| Q2 | 1.01 (0.77–1.34) | 1.01 (0.76–1.33) | 1.02 (0.76–1.36) |
| Q3 | 0.96 (0.73–1.27) | 0.96 (0.73–1.27) | 0.95 (0.71–1.26) |
| Q4 | 1.54 (1.20–1.99) | 1.54 (1.19–1.99) | 1.46 (1.12–1.91) |
| AST | |||
| Q1 | 1 (Reference) | 1 (Reference) | 1 (Reference) |
| Q2 | 0.76 (0.57–1.01) | 0.75 (0.56–1.01) | 0.92 (0.68–1.25) |
| Q3 | 0.94 (0.70–1.24) | 0.93 (0.70–1.24) | 1.19 (0.87–1.61) |
| Q4 | 1.37 (1.05–1.78) | 1.36 (1.05–1.78) | 1.72 (1.30–2.29) |
| GGT | |||
| Q1 | 1 (Reference) | 1 (Reference | 1 (Reference) |
| Q2 | 1.44 (1.06–1.94) | 1.44 (1.07–1.96) | 1.33 (0.97–1.82) |
| Q3 | 1.36 (1.00–1.84) | 1.37 (1.01–1.86) | 1.14 (0.83–1.58) |
| Q4 | 1.84 (1.38–2.48) | 1.86 (1.39–2.50) | 1.44 (1.05–1.97) |
|
| |||
|
Elevated NT-proBNP (>400 pg/mL)
| |||
| ALT | |||
| Q1 | 1 (Reference) | 1 (Reference) | 1 (Reference) |
| Q2 | 0.71 (0.53–0.97) | 0.74 (0.54–1.01) | 0.81 (0.59–1.12) |
| Q3 | 0.53 (0.38–0.74) | 0.57 (0.40–0.79) | 0.64 (0.45–0.92) |
| Q4 | 0.40 (0.28–0.58) | 0.44 (0.30–0.63) | 0.49 (0.33–0.72) |
| AST | |||
| Q1 | 1 (Reference) | 1 (Reference) | 1 (Reference) |
| Q2 | 0.82 (0.58–1.14) | 0.86 (0.61–1.20) | 0.94 (0.66–1.35) |
| Q3 | 0.79 (0.56–1.12) | 0.87 (0.61–1.23) | 0.92 (0.63–1.33) |
| Q4 | 0.58 (0.40–0.83) | 0.64 (0.45–0.93) | 0.67 (0.46–0.99) |
| GGT | |||
| Q1 | 1 (Reference) | 1 (Reference) | 1 (Reference) |
| Q2 | 0.70 (0.49–0.99) | 0.68 (0.48–0.97) | 0.73 (0.51–1.06) |
| Q3 | 1.03 (0.73–1.45) | 1.04 (0.74–1.46) | 1.15 (0.80–1.65) |
| Q4 | 0.95 (0.68–1.34) | 0.96 (0.69–1.37) | 0.98 (0.67–1.43) |
Model 1: age (years), race-center, sex, education (less than high school, high school, college or above)
Model 2: variables in Model 1 + smoking (current, former, or never smoker), alcohol consumption (current, former, or never drinker)
Model 3: variables in Model 2+ body mass index (kg/m2), systolic blood pressure (mm/Hg), diastolic blood pressure (mm/Hg), fasting glucose (mg/dL), LDL (mg/dL) and HDL-cholesterol (mg/dL), hypertension medication use, C-reactive protein (mg/L) and eGFR (mL/min/1.73m2)