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. Author manuscript; available in PMC: 2015 Mar 25.
Published in final edited form as: Curr Top Med Chem. 2014;14(13):1606–1618. doi: 10.2174/1568026614666140827144752

Table 2.

Antagonism of DAMGO and RANTES stimulated calcium mobilization in hMOR-CHO and MOLT-4 cells respectively.

Compound MOR IC50 (nM)a CCR5 IC50 (nM)b
28 8.9 ± 0.9 -
29 - 2.2 ± 0.3
22 40.0 ± 4.8 126 ± 28
23 - 622 ± 36
24 37.8 ± 4.4 -
25 - 7.91 ± 0.76
26 - 1.57 ± 0.18
27 - 14.2 ± 1.9
a

hMOR-CHO cells were stimulated with DAMGO,

b

MOLT-4 cells were stimulated with RANTES, (-) denotes that the compound was not tested [75].