Table 2. Regression coefficients (B), confidence intervals (CI), and p-values (p) of multivariate regression analyses of age, sex, body mass index (BMI), hypertension, hyperlipidemia, diabetes, active smoking, platelet count, white blood cell count (WBC), log transformed interleukin-6 (log IL-6),log transformed high-sensitivity C-reactive protein (log hsCRP), log transformed serum creatinine (log creatinine), and log transformed asymmetric dimethylarginine (log ADMA) for surface expression of P-selectin, activation of glycoprotein (GP) IIb/IIIa, and formation of monocyte-platelet aggregates (MPA).
P-selectin (MFI) | Activated GPIIb/IIIa (MFI) | MPA formation (%) | |||||||
---|---|---|---|---|---|---|---|---|---|
B | CI | P | B | CI | p | B | CI | P | |
Age | 0.01 | -0.01–0.03 | 0.3 | 0.01 | -0.01–0.02 | 0.3 | -0.1 | -0.2–0.01 | 0.06 |
Female sex | 0.03 | -0.4–0.5 | 0.9 | 0.09 | -0.2–0.4 | 0.5 | 0.7 | -1.6–3 | 0.5 |
BMI | -0.02 | -0.07–0.03 | 0.5 | -0.01 | -0.03–0.02 | 0.7 | -0.01 | -0.3–0.2 | 0.9 |
Hypertension | -0.3 | -1–0.4 | 0.4 | 0.1 | -0.3–0.5 | 0.5 | -2.4 | -5.9–1.2 | 0.2 |
Hyperlipidemia | 0.2 | -0.6–1 | 0.6 | 0.04 | -0.4–0.5 | 0.9 | 2.6 | -1.3–6.5 | 0.2 |
Diabetes | 0.3 | -0.1–0.7 | 0.1 | 0.2 | -0.08–0.4 | 0.2 | -0.4 | -2.5–1.7 | 0.7 |
Smoking | 0.3 | -0.1–0.8 | 0.2 | -0.05 | -0.3–0.2 | 0.7 | -2.3 | -4.6 –-0.1 | 0.04 |
Platelet count | 0 | -0.004–0.003 | 0.8 | -0.001 | -0.003–0.001 | 0.4 | 0.05 | 0.03–0.07 | <0.001 |
WBC | -0.06 | -0.1–0.01 | 0.1 | -0.03 | -0.08–0.01 | 0.1 | -0.3 | -0.7–0.1 | 0.2 |
Log IL-6 | 1.1 | 0.4–1.7 | 0.003 | 0.4 | 0.05–0.8 | 0.03 | 3.6 | 0.1–7 | 0.04 |
Log hsCRP | 0.2 | -0.2–0.7 | 0.3 | 0.05 | -0.2–0.3 | 0.7 | 0.4 | -1.7–2.6 | 0.7 |
Log creatinine | -0.05 | -2.1–2 | 0.9 | 0.4 | -0.8–1.6 | 0.5 | -1.6 | -11.5–8.4 | 0.8 |
Log ADMA | 0.04 | -0.5–0.6 | 0.9 | 0.4 | 0.08–0.7 | 0.02 | 0.9 | -1.8–3.5 | 0.5 |
MFI, mean fluorescence intensity.