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. 2015 Mar 23;9:31–38. doi: 10.4137/CMO.S23252

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© 2015 the author(s), publisher and licensee Libertas Academica Ltd.

This is an open-access article distributed under the terms of the Creative Commons CC-BY-NC 3.0 License.

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Changes in CT findings of pelvic LN metastases. Before injection, multiple metastatic pelvic LNs were observed. After the third injection, almost complete necrosis of the injected lt. obturator LN was observed, illustrating Ad-REIC induced powerful direct effects. Similar necrotic changes of non-injected external and common iliac LNs were observed, illustrating the induction of strong indirect effects of Ad-REIC. After the sixth injection, cytoreductive effects were clearly seen and external and common iliac LNs were not detected after the 15th injection.