LC-MS analysis of CPE, SM, ceramide, and hexoyslceramide species in forebrain, cerebellum, and liver of wild-type, SMSrD348E, SMS2gt×SMSrD348E, and SMS2gt mice. A–C: Analysis of main CPE species. D, E: Analysis of main SM species. F–H: Analysis of main ceramide species. I–K: Analysis of main hexosylceramide (Hex-Cer) species. Data are means ± SEM; *P < 0.05, **P < 0.005, ***P < 0.001; n = 3–4.