Fig. 5.

Loss of lipin-1-mediated PAP activity does not affect weight gain or glucose tolerance on HTF-C chow. A: Body weight gain of WT and Alb-Lpin1^−/− mice on HTF-C diet for 10 weeks is shown. B: Glucose tolerance was quantified in WT and Alb-Lpin1^−/− mice fed HTF-C diet for 10 weeks. C: Hepatic insulin signaling was measured by Western blotting for phosphorylation of proteins in that signaling cascade. The quantification of the normalized (WT saline = 1.0) ratio of phosphorylated to total protein abundance is shown in the graphs inset (n = 4). * P < 0.05 versus no insulin mice of the same genotype.