Fig. 1.

Addition of unsaturated (but not saturated) LPA to standard mouse chow results in dyslipidemia and decreased PON activity. Female LDLR^−/− mice 4–6 months of age (20–22 per group) were fed standard mouse chow, or standard mouse chow supplemented with 1 μg per gram chow of LPA 18:0 or LPA 18:2, or the mice were fed a WD. Some of the mice also received 2.2% by weight of freeze-dried EV tomatoes or Tg6F tomatoes. After 13 weeks, the mice were fasted overnight, and 20 mice from each group were bled to determine plasma lipids and PON activity as described in Materials and Methods. A: Plasma total cholesterol levels. B: Plasma triglyceride levels. C: Plasma HDL-cholesterol levels. D: Plasma PON activity. The data shown are mean ± SEM. NS, not significant.