Fig. 6.

Adding LysoPC 18:1 to standard mouse chow dose-dependently produces dyslipidemia and inflammation in LDLR^−/− mice. Female LDLR^−/− mice 4–6 months of age (20 per group) were fed mouse chow or mouse chow supplemented with LysoPC 18:1 at a dose of 0.1 mg/g chow, 0.5 mg/g chow, 1.0 mg/g chow, or 2 mg/g chow. After 2 weeks, the mice were fasted overnight, and blood was collected for determination of plasma lipids and SAA as described in Materials and Methods. A: Plasma total cholesterol levels. B: Plasma triglyceride levels. C: Plasma HDL-cholesterol levels. D: Plasma SAA levels. The data shown are mean ± SEM. NS, not significant. If chow is included in multiple comparisons, each comparison is to chow.