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. 2015 Apr;56(4):871–887. doi: 10.1194/jlr.M056614

Fig. 7.

Fig. 7.

The dyslipidemia induced by supplementing standard mouse chow with LysoPC 18:1 is significantly ameliorated by adding a specific autotaxin inhibitor (PF8380). Male LDLR−/− mice 9–10 months of age (20 per group) were fed standard mouse chow or standard mouse chow plus LysoPC 18:0 or LysoPC 18:1 at 1 mg per gram chow without or with 30 mg/kg of the specific oral autotaxin inhibitor PF8380, or the mice were fed standard mouse chow supplemented with LPA 18:1 at 1 μg per gram chow without or with 30 mg/kg of PF8380, or the mice were fed a WD. After 2 weeks, the mice were fasted overnight, bled, and plasma lipids and PON activity were determined as described in Materials and Methods. A: Plasma total cholesterol levels. B: Plasma triglyceride levels. C: HDL-cholesterol levels. D: PON activity. The data shown are mean ± SEM. NS, not significant. If chow is included in multiple comparisons, each comparison is to chow.