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. 2015 Apr;56(4):871–887. doi: 10.1194/jlr.M056614

Fig. 8.

Fig. 8.

Adding LysoPC 18:0 or LysoPC 18:1 or LPA 18:1 to standard mouse chow produces complex changes in the levels of LPA species in the tissue of the jejunum. Male LDLR−/− mice 5–7 months of age (20 per group) were fed standard mouse chow or standard mouse chow plus LysoPC 18:0 or LysoPC 18:1 at 1 mg per gram chow without or with 30 mg/kg of the specific oral autotaxin inhibitor PF8380, or the mice were fed standard mouse chow supplemented with LPA 18:1 at 1 μg per gram chow without or with 30 mg/kg of PF8380, or the mice were fed a WD. After 2 weeks, the mice were fasted overnight; under anesthesia, the mice were bled and perfused to remove all blood as described in Materials and Methods; and the jejunum was harvested and processed to determine LPA tissue levels as described in Materials and Methods. A: The levels of LPA 16:0. B: The levels of LPA 18:0. C: The levels of LPA 18:1. D: The levels of LPA 18:2. E: The levels of LPA 20:4. The data shown are mean ± SEM. NS, not significant. If chow is included in multiple comparisons, each comparison is to chow.