Fig. 5.
Histological analysis of articular chondrocytes in Novdel3−/− and Novdel3+/+ knee joints at 2, 6 and 12 months. A: Chondrocyte density measurements (n = 4 at each age, genotype and sex). B: Cartilage thickness (n = 4 at each age, genotype and sex). C: Percentage of cells positive for immunohistochemical staining with anti-PARP p85 antibody apoptotic marker (n = 4 at each age, genotype and sex). D: Percentage of cells positive for immunohistochemical staining with anti-PCNA antibody proliferation marker (n = 4 at each age, genotype and sex). No PARP p85 positive cells were detected at 2 months (data not shown). Graphs depict mean (±95% CI), P values indicated.