Table 1. Protein functions dysregulated in NOX1 reduced cells.

Spot	Best homologue		Gene	Accession number	shNOX1 regulation (2DE)		Total score	Matched spectra	Unique peptindes	Sequence coverage	WB validation
	Protein name	Abbrev.			Fold	p value a					Fold	p value b
1	Protein SET	SET	SET	Q01105	0.5	0.008	138	11	5	20%	1.4	0.001
2	Protein SET	SET	SET	Q01105	0.4	0.001	91	10	5	22%
3	Protein SET	SET	SET	Q01105	0.3	0.003	48	4	3	14%
4	Protein SET	SET	SET	Q01105	0.3	0.007	53	5	3	14%
5	Methylosome protein 50	MEP50	WDR77	Q9BQA1	0.5	0.048	184	17	5	19%
6	Methylosome protein 50	MEP50	WDR77	Q9BQA1	0.6	0.002	723	59	11	44%
8	Proteasome activator PA28 subunit beta	PA28b	PSME2	Q9UL46	0.5	0.001	453	52	12	41%
9	Annexin A3	Annexin A3	ANXA3	P12429	0.5	0.023	919	100	16	50%
11	Hydroxymethylglutaryl-CoA synthase, cytoplasmic	HMG-CoA synthase	HMGCS1	Q01581	0.6	0.023	843	63	21	49%	0.5	0.007
12	Alpha-fetoprotein precursor	Alpha-fetoprotein	AFP	P02771	0.6	0.044	3672	395	40	75%	0.6	0.037
13	Phosphoenolpyruvate carboxykinase [GTP], mitochondrial	PEPCK-M	PCK2	Q16822	0.5	0.007	384	28	9	16%
	Serum albumin	Serum albumin	ALB	P02768			61	6	5	8%
14	Serum Albumin	Serum albumin	ALB	P02768	0.5	0.000	967	152	32	54%
16	Serum Albumin	Serum albumin	ALB	P02768	0.5	0.001	2741	425	45	71%
17	Elongation factor 2	EF2	EEF2	P13639	0.6	0.007	675	67	30	36%
18	Long chain fatty acid-CoA ligase 1 (Acsl1)	Acsl1	ACSL1	P33121	2.6	0.002	587	46	14	26%	9.8	0.037
19	Phosphoenolpyruvate carboxykinase [GTP], mitochondrial	PEPCK-M	PCK2	Q16822	0.4	0.024	142	4	3	5%
20	Phosphoenolpyruvate carboxykinase [GTP], mitochondrial	PEPCK-M	PCK2	Q16822	0.5	0.002	1201	61	15	24%
21	Fascin	Fascin, p55	FSCN1	Q16658	2.3	0.001	11324	770	31	62%	1.3	0.027
	Glutamate dehydrogenase 1, mitochondrial	GDH1	GLUD1	P00367			417	95	21	41%	1.4	0.006
22	Fascin	Fascin, p55	FSCN1	Q16658	2.1	0.001	9861	593	37	74%
	Glutamate dehydrogenase 1, mitochondrial	GDH1	GLUD1	P00367			180	30	15	29%
23	UTP—glucose-1-phosphate uridylyltransferase	UDPGP	UGP2	Q16851	1.7	0.007	2302	161	18	38%	2.2	0.000
	Fascin	Fascin, p55	FSCN1	Q16658			244	38	7	15%
24	Aspartate aminotransferase, cytoplasmatic	cAspAT	GOT1	P17174	0.5	0.001	10141	736	41	77%
25	Guanosine monophosphate reductase 2	GMP reductase	GMPR2	Q6PKC0	0.6	0.027	750	86	19	53%
26	Annexin A2 isoform 2	Annexin A2	ANXA2	P07355	0.3	0.002	2994	227	31	77%
27	Dicarbonyl reductase HEP27	HEP27	DHRS2	Q13268	0.5	0.002	530	39	20	68%
28	Dicarbonyl reductase HEP27	HEP27	DHRS2	Q13268	0.5	0.004	8124	441	32	85%
29	Dicarbonyl reductase HEP27	HEP27	DHRS2	Q13268	0.4	0.001	5456	304	22	69%
30	Dicarbonyl reductase HEP27	HEP27	DHRS2	Q13268	0.4	0.000	10917	711	47	87%

^a adjusted for FDR,

^b one tailed Welch t test for unequal variance.