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Dose-Response Relationships for Effects of Caffeine on Locomotor Activity in Mice (Nikodijevic et al., 1993a). Activity was measured for 30 min in a circular arena after intraperitoneal injection of caffeine in control and chronic caffeine male NIH Swiss strain mice. Caffeine ingestion (100 mg/kg/day) was for 7 days. followed by 2-4 hr withdrawal for caffeine clearance.
