Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. Author manuscript; available in PMC: 2015 Mar 25.

Published in final edited form as: Pharmacopsychoecologia. 1994;7(2):201–213.

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

PMC Copyright notice

Fig. 5 — Dose-Dependent Effects of NECA on Open-Field Locomotor Activity of Mice in the Presence of a Central Stimulant (Nikodijevic et al., 1993b; Shi et al., 1994). A. Caffeine (5 mg/kg). B. Amphetamine (1 mg/kg). C. Cocaine (20 mg/kg}. D. Scopolamine (1 mg/kg}. Male NIH Swiss strain mice were injected intrapcritoneally with a central stimulant (caffeine, amphetamine, cocaine, scopolamine) and varying doses of the adenosine analog NECA and open-field locomotor activity was measured for a 30 minute period. Caffeine ingestion (100 mg/kg/day) was for 4 days, followed by 2-4 hr withdrawal for caffeine clearance.

Fig. 5 — Dose-Dependent Effects of NECA on Open-Field Locomotor Activity of Mice in the Presence of a Central Stimulant (Nikodijevic et al., 1993b; Shi et al., 1994). A. Caffeine (5 mg/kg). B. Amphetamine (1 mg/kg). C. Cocaine (20 mg/kg}. D. Scopolamine (1 mg/kg}. Male NIH Swiss strain mice were injected intrapcritoneally with a central stimulant (caffeine, amphetamine, cocaine, scopolamine) and varying doses of the adenosine analog NECA and open-field locomotor activity was measured for a 30 minute period. Caffeine ingestion (100 mg/kg/day) was for 4 days, followed by 2-4 hr withdrawal for caffeine clearance.