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. 2015 Mar 25;10(3):e0120587. doi: 10.1371/journal.pone.0120587

Fig 8. TSA activates caspase 3 but inhibits the activation of Akt and p42/44 in BCECs.

Fig 8

(A) BCECs were treated with 0–0.7 μM TSA for 24 h. TSA activates caspase 3 at the concentrations of 0.5 and 0.7 μM, and blocks Akt phosphorylation in a dose-dependent manner. In untreated cells and cells treated with low concentrations of TSA (0.05–0.1 μM), p42/44 was activated, but the activation was completely obliterated at higher TSA concentrations (0.3–0.7 μM). (B) Densitometry data for Western blot results. (*: t test p<0.05).