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. 2015 Mar 25;10(3):e0122196. doi: 10.1371/journal.pone.0122196

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© 2015 Brzoska et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Fig 3 — The kinetics of Glu-plg-568 accumulation are shown as an increase in the integrated fluorescence intensity of Glu-plg-568 per corresponding thrombus area in the same optical section 60 minutes after laser-induced thrombus formation. Reagents were EACA (closed squares, N = 5, 5 thrombi from 3 mice, p < 0.001), CPB (closed diamond, N = 5, 5 thrombi from 5 mice, p < 0.005) and aprotinin (open circles, N = 4, 4 thrombi from 2 mice, p < 0.001). Control experiments are shown as open squares (N = 5, 5 thrombi from 5 mice) and mini-plg-568 as closed circles (N = 4, 4 thrombi from 4 mice, p < 0.001). This assay was analyzed with repeated measures ANOVA. Each point represents the mean ±SD; N = number of thrombi.