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. 2015 Mar 25;10(3):e0122196. doi: 10.1371/journal.pone.0122196

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© 2015 Brzoska et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Fig 7 — (A) Glu-plg-568 was administered to GFP-mice 10 minutes before each laser injury and 40 minutes after either human tPA (white: square, diamond, circle; three individual experiments) or an equivalent volume of 0.9% NaCl (black: square, diamond, circle; three individual experiments) was infused. Thrombi images were collected every 5 minutes after the laser-evoked endothelial injury, starting 2 minutes before and then every 5 minutes up to 60 minutes after either tPA or saline infusion. Each fluorescence intensity was normalized to the value obtained 2 minutes before either tPA or saline administration. tPA or saline was injected at time 0 (arrow). (B) Shown are the Glu-plg-568 accumulation increase ratios, which were expressed as the average values of the maximum increases in Glu-plg-568 relative fluorescence intensity after administration of either tPA (mean ± SD, n = 3, white column) or saline (mean ± SD, n = 3, black column). This assay was analyzed with a t-test for independent samples (P < 0.05).