Levels of specific IgG titres were measured against CSP (1A), PfSE (1B), MSP-3 (1C) and GLURP R0 (1D) in HEU and HUU at three time points, 6 months (during CTX prophylaxis), 12 months (At stopping CTX prophylaxis) and 18 months (6 months after CTX prophylaxis). X-axis represents age of children in months. Black horizontal bars represent medians. Black lines represent differences in the median titres between groups at each time point. Blue lines represent a significant change in levels of IgG titres from baseline in each group. Significant differences are indicated in asterices: Fig. 1A # (p = 0.0401), ## (p = 0.0018), Fig. 1B *(p = 0.038), **(p = 0.0012), ***(p = 0.0097), Fig. 1C # (p = 0.0463), Fig. 1D # (p = 0.0016), ## (p = 0.0007)