Table 3. Prevalence of specific IgG positive response against P. falciparum blood stage antigens in HEU and HUU children at different ages.
Age a | Outcome | AMA-1 | MSP-119 | MSP-3 | PfSE | GLURP R0 | EBA-175 RII | GLURP R2 | ||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
HEU | HUU | P b | HEU | HUU | P | HEU | HUU | P | HEU | HUU | P | HEU | HUU | P | HEU | HUU | P | HEU | HUU | P | ||
6 c | % Pos f | 16.1 | 51.9 | 0.04 * | 6.5 | 14.8 | 0.40 | 0 | 3.7 | 0.47 | 6.5 | 3.7 | 1.0 | 3.2 | 7.4 | 0.59 | 22.6 | 22.2 | 1.0 | 6.45 | 11.1 | 0.66 |
12 d | % Pos | 3.5 | 0 | 1.0 | 12.0 | 44.0 | 0.025 * | 20.7 | 11.1 | 0.47 | 3.45 | 14.8 | 0.19 | 13.8 | 14.8 | 1.0 | 41.8 | 33.3 | 0.59 | 10.3 | 14.8 | 0.70 |
18 e | % Pos | 6.9 | 7.7 | 1.0 | 13.8 | 26.9 | 0.31 | 17.2 | 11.5 | 0.71 | 13.8 | 11.5 | 1.0 | 48.3 | 23.1 | 0.09 | 6.9 | 19.2 | 0.24 | 10.3 | 7.7 | 1.0 |
Total | % Pos | 8.9 | 20.0 | 0.04 * | 10.6 | 28.2 | 0.01 * | 12.4 | 8.8 | 0.47 | 7.87 | 10.0 | 0.79 | 21.3 | 15.0 | 0.32 | 23.6 | 25.0 | 0.86 | 8.9 | 11.3 | 0.80 |
aAge in months
bP value determined by Fisher’s exact test for the comparison of the proportion of positive IgG responses
cNumber of samples at 6 months of age: HEU (n = 31) and HUU (n = 27)
dNumber of samples at 12 months of age: HEU (n = 29) and HUU (n = 27)
eNumber of samples at 18 months of age: HEU (n = 29) and HUU (n = 26)
fProportion (% Pos) of positive responders to each antigen
* Statistically significant difference at alpha level of 0.05