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. 2015 Mar 25;11(3):e1004767. doi: 10.1371/journal.ppat.1004767

Fig 3. Cross-competition analysis for bNAb binding to BG505 SOSIP.664 trimer by SPR.

Fig 3

(A) Competition between 8ANC195 (competitor) and PGT151 and 35O22. Association-dissociation curves of the individual binding experiments were overlaid with the second association phase to detect competition. 0 on the y axis is the baseline for the single comparator injection and for the same analyte as the second in the double injection. Thus, the strength of all three responses can be read on the same scale, although the value for the first analyte in the double injection will be negative. (B) Competition between PGT151 (competitor) and 8ANC195 and 35O22. (C) Competition between 35O22 (competitor) and 8ANC195 and PGT151.