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Model for transcriptional regulation of macrophage colony-stimulating factor receptor (Csf1r) and Hox genes by mixed lineage leukemia (MLL) fusion proteins. MLL fusions induce the rapid onset of acute myeloid leukemia by activating two classes of pathways, the CSF-1R and Hox pathways. Left, MLL fusions stimulate constitutive CSF-1R expression by binding to PU.1 to induce leukemia. Right, MLL fusion proteins form a complex with menin and LEDGF to regulate the expression of Hox genes.
