Table 3.
Multivariable predictors of new onset DNP in the mixed effects logistic regression. Covariate effects are adjusted for other variables in the model. No covariate-time interactions were significant. N=493 subjects, 2306 visits.
| Covariate Effect | ||||
|---|---|---|---|---|
| Covariates1 | Covariate Levels | OR | 95 % CI | p |
| Time* | NA | 0.992 | (0.88, 1.12) | 1.000 |
| Age | Per year | 1.037 | (1.00, 1.08) | 0.064 |
| Gender | Male vs Female | 0.47 | (0.22, 0.980) | 0.150 |
| Plasma VL at entry | Undetectable | Ref 2 | -- | 0.038 |
| Detectable | 1.54 | (1.007, 2.35) | -- | |
| CART Use at study entry | Never Used | Ref 2 | -- | 0.0072 |
| Current | 2.44 | (1.026, 5.80) | -- | |
| Past Use | 4.59 | (1.51, 13.97) | -- | |
| Lifetime history of Opioid Abuse/ Dependence | No | Ref 2 | -- | -- |
| Yes | 2.31 | (1.078, 4.95) | 0.014 | |
| Time-updated Severity of depressive symptomatology | BDI-II 0-13 | Ref 2 | -- | 0.0017 |
| BDI-II 14-19 | 1.66 | (0.922, 3.00) | -- | |
| BDI-II 20-28 | 1.89 | (1.026, 3.49) | -- | |
| BDI-II 29-63 | 2.99 | (1.41, 6.31) | -- | |
1
All covariates entered into this model were significant (α = 0.15) in the univariable analysis
2
Odds ratios calculated by comparison to a reference group comprising individuals on CART with undetectable plasma VL at study entry and all follow-up visits (i.e., optimally treated), without depressed mood at study entry and having no history of substance abuse or dependence.
ref: reference level (OR=1)
BDI-II, Beck Depression Inventory, Second Edition.