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. Author manuscript; available in PMC: 2015 Mar 26.
Published in final edited form as: Br J Sports Med. 2014 Jun 19;48(15):1172–1178. doi: 10.1136/bjsports-2014-093840

Table 2.

Personal and family history responses to the PPE-4 Monograph before and after review with a physician

PPE-4 personal and family history
All students (1339)
Total positive (%) before physician evaluation Total positive (%) after physician evaluation
≥1 Positive personal or family history response 916 (68) 421 (31)
Personal history questions
    Have you ever had discomfort, pain, tightness or pressure in your chest during exercise? 377 (28) 217 (16)
    Do you get light-headed or feel more short of breath than expected during exercise? 341 (25) 210 (16)
    Do you get more tired or short of breath more quickly than your friends during exercise? 295 (22) 165 (12)
    Have you ever passed out or nearly passed out DURING or AFTER exercise? 167 (12.5) 126 (9)
    Does your heart ever race or skip beats (irregular beats) during exercise? 149 (11) 100 (7.5)
    Has a doctor ever ordered a test for your heart? (For example, an ECG/EKG, echocardiogram) 116 (9) 79 (6)
    Has a doctor ever told you that you have any heart problems? If so, check all that apply: 99 (7) 70 (5)
        Heart murmur 54 (4) 38 (2.8)
        High blood pressure 22 (1.6) 16 (1)
        High cholesterol 7 (0.5) 2 (<0.5)
        Kawasaki disease 2 (<0.5) 2 (<0.5)
        Unknown 1 (<0.5) 1 (<0.5)
        Heart infection 0 0
        Marfan syndrome 0 0
    Have you ever had an unexplained seizure? 19 (1.4) 13 (1)
Family history questions
    Does anyone in your family have a heart problem, pacemaker or implanted defibrillator? 339 (25) 165 (12)
    Has any family member or relative died of a heart problem or had any unexpected or unexplained sudden death before age 50 (including drowning, unexplained car accident or sudden infant death syndrome)? 211 (16) 118 (9)
    Has anyone in your family had unexplained fainting, unexplained seizures or near drowning? 129 (10) 77 (6)
    Does anyone in your family have a known cause of SCD: 46 (3.4) 36 (2.7)
        Hypertrophic cardiomyopathy 11 (0.8) 10 (0.75)
        Marfan syndrome 4 (0.3) 4 (0.3)
        CPVT 3 (0.2) 2 (0.2)
        Short QT syndrome 1 (<0.1) 1 (<0.1)
        Long QT syndrome 1 (<0.1) 1 (<0.1)
        ARVC 0 0
        Brugada syndrome 0 0
        Unknown 13 (1) 11 (1)
        Other 11 (0.8) 6 (0.5)

ARVC, arrhythmogenic right ventricular cardiomyopathy; CPVT, catecholaminergic polymorphic ventricular tachycardia; PPE-4, Pre-participation Physical Evaluation 4th Edition; SCD, sudden cardiac death.