Fig. 4.

Propionibacterium acnes-induced phosphorylation of p38, but not of ERK1/2 or JNK1/2, and the cytokine release was inhibited by a p38α inhibitor, SCIO-469, in human keratinocytes. a Western blots show that SCIO-469 inhibits P. acnes-induced phospho-p38 (p-p38) dose-dependently, but not of phospho-ERK1/2 (p-ERK1/2) or phospho-JNK1/2 (p-JNK1/2). b–c SCIO-469 inhibits the secretion of TNF-α (b), IL-8 (c), and IL-1α (d). Data are expressed as mean ± SD. p < 0.05 (*), p < 0.01 (**), p < 0.005 (***). ERK extracellular signal-related kinases, JNK c-Jun N-terminal kinases, TNF tumor necrosis factor, IL interleukin, PA Propionibacterium acnes