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Propionibacterium acnes-induced phospho-p38 and cytokine release was inhibited by a p38α inhibitor, SCIO-469, in human epidermal equivalents. a Western blot shows that SCIO-469 suppresses P. acnes-induced phospho-p38 (p-p38) dose-dependently. b–c SCIO-469 inhibits the secretion of TNF-α (b) and IL-8 (c). Data are expressed as mean ± SD. p < 0.05 (*), p < 0.01 (**), p < 0.005 (***). PA Propionibacterium acnes, TNF tumor necrosis factor, IL interleukin
