Table 3.

Analyses of clinical variables according to death or survival in non-diabetic patients with severe hypoglycemia

Variable	Hazard ratio	95 % CI	P value
Univariate analysis
Age (years)	1.03	1.01–1.06	0.003
≥65	2.64	1.14–6.10	0.02
Women	0.81	0.40–1.63	0.56
Preexisting diseases
Hypertension	1.58	0.75–3.32	0.22
Atrial fibrillation	1.44	0.34–6.05	0.61
Advanced liver disease	7.40	2.79–19.63	<0.001
Cancer	2.90	1.01–8.32	0.04
QTc ≥0.50 s	1.26	0.33–4.80	0.72
Coexisting sepsis	3.91	1.96–7.82	<0.001
Blood glucose (mg/dL)	0.96	0.94–0.98	<0.001
<40	4.65	1.91–11.31	0.001
Multivariate analysis
Age (years) ≥65	3.42	1.33–8.81	0.01
Advanced liver disease	9.68	3.24–28.86	<0.001
Cancer	3.64	1.22–10.88	0.02
Sepsis	3.17	1.55–6.48	0.002
Blood glucose (mg/dL) <40	3.75	1.52–9.27	0.004

Data are represented as the hazard ratio or 95 % CI. To convert blood glucose to mmol/L, multiply by 0.0555

Advanced liver disease was defined as the presence of cirrhosis or hepatocellular carcinoma

Cancer was defined as any cancer excluding hepatocellular carcinoma and fully healed cancer

QTc was calculated using Bazett’s formula: QTc = QT interval ÷ square root of the RR interval

Sepsis was defined as the presence of systemic inflammatory response syndrome in response to infection. Systemic inflammatory response syndrome was regarded as the presence of two or more of the following criteria: body temperature >38 or <36 °C, heart rate >90 beats per minute, respiratory rate >20 breaths per minute, and white blood cell >12,000 per mm³

CI confidence interval