Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2015 Mar 26;5:9493. doi: 10.1038/srep09493

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2015, Macmillan Publishers Limited. All rights reserved

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder in order to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

PMC Copyright notice

(A1–C1) The effects of 10 μM D-AP5 on 1 μM nicotine's role on γ. (A1): Representative extracellular recordings of field potentials in the presence of KA (200 nM) alone, KA + D-AP5 (10 μM) and KA + D-AP5 + NIC (1 μM). (B1): The power spectra of field potentials corresponding to the conditions shown in A1. (C1): Time course shows the changes in γ power before and after application of NIC in the presence of D-AP5. A2-B2: The effects of 10 μM D-AP5 on 10 μM nicotine's role on γ. (A2): Representative extracellular recordings of field potentials in the presence of KA alone, KA + D-AP5 (10 μM) and KA + D-AP5 + NIC (10 μM). (B2): The power spectra of field potentials corresponding to the conditions shown in A2. (A3–B3) The effects of 10 μM AP5 on 100 μM nicotine's role on γ. (A3): Representative extracellular recordings of field potentials in the presence of KA, KA + D-AP5 (10 μM) and KA + D-AP5 + NIC (100 μM). (B3): The power spectra of field potentials corresponding to the conditions shown in A3. (D): The bar graph summarizes the percent changes in γ power before (gray bars) and after various concentrations of nicotine (1–100 μM) in the presence of 10 μM D-AP5. 10 μM D-AP5 had no effect on γ oscillations (shallow dark bars) and the subsequent application of 1 μM nicotine had no significant effect on γ power (n = 17, black bars). 10 μM D-AP5 also blocked the roles of higher concentrations of nicotine (10 μM, n = 12; 100 μM, n = 6) on γ power. (E): The bar graph summarizes the percent changes in γ power before and after various concentrations of nicotine (1–100 μM) in the presence of 1 μM D-AP5. 1 μM D-AP5 had no effect on γ oscillations (shallow dark bars) and the subsequent application of 1 μM nicotine had no significant effect on γ power (n = 8, black bars). Similarly, 1 μM D-AP5 also blocked the roles of nicotine at higher concentrations of 10 μM (n = 8) and 100 μM (n = 8) on γ power.