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. 2015 Mar 23;6:6597. doi: 10.1038/ncomms7597

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(a) Regular stereotypic epileptiform discharges (average frequency: 0.15±0.05 Hz; n=3) induced in Mg²⁺-free aCSF. Insert: sample field potential recording traces. (b) An example of a large GABA_AR-mediated current in a CA1 pyramidal neuron (black, whole-cell voltage clamp, V_hold=0 mV) associated with a field potential (f.p.) burst (blue). (c) Typical recording of GABA_AR-mediated drive onto a pyramidal neuron (V_hold=0 mV) during epileptiform activity. PTX, picrotoxin; TTX, tetrodotoxin. (d) Time course of I_hold changes induced by co-application of SKF89976A and SNAP5114 in control and Mg²⁺-free aCSF (rate of I_hold increase calculated 1–5 min after GAT inhibitors application in 0 Mg²⁺: 1.1±0.2 pA s⁻¹; in control: 0.16±0.04 pA s⁻¹; n=4 for each condition; P=0.004, t-test). (e) GAT inhibitors suppress the frequency of epileptiform discharges (3.6±2.6% of baseline; n=4, P<0.001, paired t-test). Error bars, s.e.m.