Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2015 Mar 23;6:6597. doi: 10.1038/ncomms7597

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2015, Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved.

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

PMC Copyright notice

(a) Changes in tonic GABA_AR-mediated currents in CA1 pyramidal neurons following application of SKF899976A during ongoing epileptiform activity (n=6; PTX, picrotoxin; TTX, tetrodotoxin; error bars, s.e.m.). (b) The effect of GAT-1 inhibition on tonic GABA_AR-mediated currents in CA1 pyramidal neurons in the absence of synaptic GABA release (slices preincubated in 1 μM concanamycin; n=6; error bars, s.e.m.). (c,d) Mean normalized traces of GABA_AR transients (grey: s.e.m.) show that SKF89976A similarly prolongs burst-associated GABA_AR transients in pyramidal neurons from control (c; area under the curve, AUC, increases from 88.8±18.2 to 188.6±53.9 ms; n=6; P=0.038, paired t-test) and epileptic hippocampi (d; AUC increase from 107.9±21.6 to 173.3±24.8 ms; n=8; P=0.0012, paired t-test). Bars, mean; error bars, s.e.m.; circles, individual experiments.