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. Author manuscript; available in PMC: 2015 Sep 15.
Published in final edited form as: Clin Cancer Res. 2015 Mar 15;21(6):1258–1266. doi: 10.1158/1078-0432.CCR-14-1429

Figure 1.

Figure 1

Different types of tumor heterogeneity. (A) Intratumor heterogeneity: the presence of multiple subclones within a primary tumor resulting in heterogeneity among tumor cells. (B) Interpatient heterogeneity: the presence of unique subclones in the tumor of each patient. (C) Intermetastatic heterogeneity: the presence of different subclones in different metastatic lesions of the same patient; some subclones may have been derived from the primary tumor and some may have emerged as a result of acquired alterations within each metastatic lesion. (D) Intrametastatic heterogeneity: the presence of multiple subclones within a single metastatic lesion.