Figure 5. In silico perturbations predict key regulators of blood development.
(a) Network stable states for wild-type and Sox7 overexpression. Red indicates expressed; blue indicates not expressed. (b) Colony assays with or without doxycycline from genotyped E8.25 embryos from iSox7+rtTA+ mice crossed with wild types. (c) Quantification of primitive erythroid colonies after 4 days (mean and s.e.m for the number of embryos indicated). P-value was determined using the student’s t-test for the number of embryos indicated.