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. 2015 Feb 3;14:24. doi: 10.1186/s12943-014-0284-y

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© Koumangoye et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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SOX4, EZH2 and HDAC3 are upregulated and inversely correlate with miR-31 in esophageal cancers. (A) qRT-PCR of SOX4, EZH2, EZH1. HDAC3 and miR-31 in 16 ESCC cell lines. Insert: correlation between mRNA expression of SOX4, EZH2, EZH1, HDAC3 and miR-31 in ESCC cell lines. Statistical analysis was done by ANOVA. (B) SOX4, EZH2, EZH1 and HDAC3 expression in primary esophageal squamous cell carcinomas, ESCC, compared to adjacent normal tissues (Geo dataset GSE20347). (C) SOX4, EZH2, EZH1 and HDAC3 expression in Barrett’s Esophagus lesions and primary esophageal adenocarcinoma tumors, EAC, compared to adjacent normal tissues (Geo dataset GSE13898). (D) Model depicting reciprocal inhibition of miR-31 and SOX4, EZH2 and HDAC3.