Figure 4.
P2X receptor antagonist oxidized ATP (oATP) inhibits the ATP-induced alkalization. (a+b) Original trace and summary (ΔpHi) of time control experiments, where a perfused medullary thick ascending limb is exposed to basolateral ATP twice with a 12-min washout period in between. (c+d) Original trace and summary (ΔpHi) of experiments, where pre-incubation with oATP (50 μm, 5-min exposure) completely inhibits the ATP-induced alkalization. *Indicates statistical significance P < 0.01, n = 6.