Table 1. A comprehensive list of dysregulated miRNAs in primary colorectal cancer tissues.

miRNA	Target gene	Chromosomal location	Reference
Up-regulated miRNA
miR-16	BMI1, WIP1, CDK6	13q14.2/3q25.33	[151,152]
miR-17	PTEN, DLC1, ZBP1, p130	13q 31.3	[47,84,153,154]
miR-18a	Dicer1, KRAS, PTEN, CTGF, ATM	13q 31.3	[155,156]
miR-20a	PTEN, RUNX1,E2F1,HIF1A	13q 31.3	[25,47,84,153,157]
miR-21	PTEN, PDCD, RECK, JAG1, BCL2, TIMP3, DKK2	17q 23.1	[31,49,84,158-160]
miR-29a	KLF4, DNMT3a, DNMT3b	7q 32.3	[153,161,162]
miR-31	FIH1, RhoBTB1, RASA1	9q 21.3	[49,153,163-165]
miR-32	PTEN	9q 31.3	[19,166-168]
miR-33	Pim1, p53, HMGA2	22q 13.2	[19,168]
miR-92a	PTEN, P63, RECK, DUSP10, ITGA5	13q 31.3/Xq 26.2	[31,47,84,153,169,170]
miR-95	SNX1, SGPP1	4p16.1	[31,47,153,162,171]
miR-96	FOXO1, RECK, RAD51, REV1	7q 32.2	[25,47,162,168,172,173]
miR-106a	PTEN, TIMP2, PDCD4, p130, RUNX3	Xq 26.2	[19,31,47,162]
miR-106b	APC, RBL1, RBL2, CASP8	7q 22.1	[47,84,162]
miR-130b	PPARγ, ITGB1, PTEN	22q 11.21	[162,174-176]
miR-135a	APC, MCL1, c-MYC, HOXA10	3q 21.1	[31,34]
miR-135b	APC, MTSS1, LATS2, β-TrCP, LZTS1	1q 32.1	[25,34,47,173]
miR-155	MLH1, MSH2, MSH6, APC, TP53, INP1	21q 21.3	[177,178]
miR-181b	CBX7, CYLD, AC9	9q 33.3	[31,84,162,179,180]
miR-182	NDRG1, RECK, MTSS1, SMAD4	7q 32.2	[153,168,181,182]
miR-183	IDH2, PDCD4, Dkk3, SMAD4	7q 32.2	[25,84,153,168,183]
miR-191	TIMP3	3p 21.31	[19,180,184]
miR-196b	HOXC8, HOXB7	7p 15.2	[153,185]
miR-200c	ZEB1, ZEB2, BMI1	12p 13.31	[177,180]
miR-203	ZEB2, BMI1, SOCS3, VEGFA	14q 32.33	[31,84,162,186]
miR-223	E2F1, FOXO1, EPB41L3	Xq 12	[31,47,84,186,187]
miR-224	SMAD4, CXR4, PHLPP1, PHLPP2	Xq 23	[47,153,162,168,188]
miR-335	RB1, ROCK1	7q 32.2	[31,86,185]
miR-493	IGF1R	14q 32.2	[153,173]
miR-584	ROCK1	5q 32	[168,173,187]
	Down-regulated miRNA
let-7a	KRAS, NRAS	9q22.32/11q24.1/22q13.31	[186,187]
miR-1	BDNF, MET, SLUG, CCND2, SDF1	18q 11.2/20q 13.33	[31,50,162,168,173,187,189]
miR-7	YY1, XRCC2	9q 21.32	[190,191]
miR-9	CXCR4, BRCA1, TLN1, ITGB1	1q22/5q14.3/15q26.1	[168,192]
miR-30a	DTL, HIF2α	6q 13	[25,31,162,168]
miR-30b	SIX, KRAS,PIK3D, BCL21	8q 24.22	[187,193,194]
miR-30c	BCL9, SNAI1	1q 34.2/6q 13	[162,187]
miR-34b/c	BTG4, MET, CDK4, CDK6, RUNX2	11q 23.1/	[31,195,196]
miR-101	EZH2, COX2, TET2	9q 24.1	[26,187,197]
miR-124a	SLUG, STAT3, EZH2, IL6R	8p23.1/8q12.3/20q13.33	[25,198,199]
miR-126	CXCR4, IRS-1, VEGF	9q34.3	[200-204]
miR-129	BCL2, CDK6, SOX4	7q32.1/11p11.2	[25,109]
miR-133a	LASP1, RFFL, FSCN1	18q 11.2/20q 13.33	[50,115,162,168,205]
miR-133b	CXCR4, MET	6p12.2	[25,189,206]
miR-137	LSD1, FMNL2, CDC42, CDK6	1p 21.3	[168,207]
miR-139	IGF1R, NR5A2	11q 13.4	[162,168,173,208]
miR-143	KRAS, DNMT3A, TLR2, MACC1	5q 32	[84,162,186,187,209]
miR-145	MUC1, KLF4, Fascin1, SOC2, YES1	5q 32	[25,84,162,173,187,210]
miR-148a	BCL2, MMP7, ROCK1	7p 15.2	[122,187,211]
miR-192	BCL2, ZEB2, VEGFA	11q 13.1	[31,186,187,212]
miR-195	BCL2, IKKα, TAB3, E2F3	17p 13.1	[162,173,187,213,214]
miR-212	MnSOD	17p 13.3	[26,215]
miR-215	RB1	1q 41	[31,84,175,186,187,212,216]
miR-218	BMI1, CDK6, DKK2	4p 15.31/5q 34	[217,218]
miR-320a	Rac1, β-catenin, NRP1	8p 21.3	[84,219,220]
miR-342	DNMT1, ID4, BMP7	14q 32.2	[31,187,221]
miR-363	GATA6, SIPR1, PDPN	Xq 26.2	[168,173]
miR-375	PI3K, PDK1, AEG1, IGF1R, YAP	2q 35	[168,187,216,222,223]
miR-378	IGF1R, MYC, VEGFA	5q 32	[168,173,187,216,224]
miR-497	IGF1R, BCL2, RAF1	17p 13.1	[113,162]