Fig. 2.

Activation of the human P2Y₂ (left panel), and P2Y₄ (right panel) receptors by ribose-modified uracil 2′-deoxynucleotide analogues containing 2′-amino (7) (▼) and 2′-azido (8) (▲) functionality. PLC activity was measured as described in Section 3.2 in 1321N1 human astrocytoma cells stably expressing the human P2Y receptors. The data are the means of triplicate determinations and are representative of results obtained in at least three separate experiments with each analog.