Table 1.
pfdhfr , pfdhps , pfcrt , and pfmdr1 haplotypes of Plasmodium falciparum isolates in Balombo area, Benguela province, central Angola
| Molecular marker (no. of isolates analysed) | No. of isolates (%) |
|---|---|
| dhfr (n = 58) | |
| Wild-type haplotype ANCSI | 2 (3.4) |
| Single mutant haplotype ANCNI | 1 (1.7) |
| Double mutant haplotype AICNI | 40 (69.0) |
| Double mutant haplotype ANRNI | 3 (5.2) |
| Triple mutant haplotype AIRNI | 12 (20.7) |
| dhps (n = 30) | |
| Wild-type haplotype SAKAA | 4 (13.3) |
| Single mutant haplotype SGKAA | 18 (60.0) |
| Double mutant haplotype AGKAA | 8 (26.7) |
| pfcrt (n = 36) | |
| Wild-type haplotype CVMNK | 4 (11.1) |
| Mutant haplotype CVIET | 32 (88.9) |
| pfmdr1 (n = 54) | |
| Wild-type haplotype, NYSND | 19 (35.2) |
| Single mutant haplotype, YYSND | 26 (48.1) |
| Single mutant haplotype, NFSND | 6 (11.1) |
| Double mutant haplotype, YFSND | 2 (3.7) |
| Double mutant haplotype, YYSNY | 1 (1.8) |
For each haplotype, mutant alleles are in bold.