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. 2014 Dec 16;20(Suppl 1):S10–S16. doi: 10.2119/molmed.2014.00167

Figure 4.

Figure 4

EPO binding the homodimeric receptor mediating red cell production via binding sites located on each receptor monomer (sites 1 and 2, as indicated in the dashed boxes). The portions of the EPO molecule interacting with the receptor consist of portions of helices A, C and D. In contrast, helix B faces away from the receptor. The exterior portion of helix B (dashed ellipse) is highly conserved from an evolutionary perspective and binds to the IRR, a heteromeric receptor consisting of EPOR and β common receptor subunits. Image reproduced from (18) (copyright © 2008 by The National Academy of Sciences of the USA).