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. Author manuscript; available in PMC: 2015 Mar 26.
Published in final edited form as: Circulation. 2012 Aug 28;126(9):1110–1120. doi: 10.1161/CIRCULATIONAHA.111.060368

Table 1. Association of metabolite clusters with coronary artery disease (CAD).

Targeted metabolomics analysis was performed on blood samples from patients with and without CAD, involving an index (initial) cohort of 174 cases and 174 controls, and a replication cohort of 140 cases and 140 controls (adapted from reference 8).

Factor Name Individual Components Initial
Cohort
P-value
Replication Cohort
P-value
Unadj Adj* Unadj Adj*

1 Medium Chain
Acylcarnitines
C8, C10:1, C12, C10, C12:1, C10-OH:C8DC, C6-DC, C8:1-
DC, C14:1, C14:2, C8:1-OH/C6:1-DC, C2 acylcarnitines
0.001 0.01 0.15 0.03
2 Long Chain
Acylcarnitines
C18:1, C18:2, C18, C16, C16:1, C20:4, C14:1, C14:2, C16:2,
C14:1-OH
0.28 0.34 0.03 0.01
3 Long Chain
Dicarboxyl/
Hydroxyl
Acylcarnitines
C18-OH/C16-DC, C20-OH/C18-DC, C20:1-OH/C18:1-DC,
C16-OH/C14-DC, C18:1-OH/C16:1-DC, C14-OH/C12-DC,
C12-OH:C10-DC, C14:1-OH, C20
0.10 0.36 <0.0001 0.004
4 BCAA Related Phe, Tyr, leu/Ile, Met, Val, C5, Ala 0.002 0.02 0.01 0.03
5 Ketone Related Ket, Hbut, Ala (−), C2, C4:OH, C14:1 0.18 0.33 0.54 0.41
6 Various C8:1, C10:3 0.56 0.75 0.79 0.92
7 Amino Acids Ser, Gly, FFA (−) 0.19 0.13 0.04 0.18
8 Dicarboxyls C5-DC, C8:1-OH/C6:1-DC, Cit, C8:1-DC, C6-DC 0.73 0.34 0.05 0.57
9 Urea Cycle
Related
Arg, His, Cit, Ci4-DC:C4DC (−) 0.0004 0.004 0.01 0.01
10 Short Chain
Acylcarnitines
C3, C4:Ci4, C5 0.02 0.19 0.72 0.92
11 Various C5:1, C18:2-OH (−), C22 (−) 0.62 0.13 0.03 0.01
12 Various Asx, C22 0.12 0.83 <.0001 <.0001
*

adjusted for diabetes, hypertension, smoking, dyslipidemia, family history, BMI; replication group additionally adjusted for age, race and sex.