Table 1.
Entire STOPStroke Cohort
| All Patients (n=649) | No IV-tPA (n=548) | IV-tPA (n=101) | p-value | |
|---|---|---|---|---|
| Men, n (%) | 330 (51%) | 281 (51%) | 49 (49%) | 0.794 |
| Age (year), mean (SD) | 68.3 ± 15.5 | 68.3 ± 15.3 | 68.4 ± 16.2 | 0.562 |
| NIHSS, median (IQR) | 5 (2–12) | 4 (2–11) | 9 (4–16) | <0.001 |
| ASPECT <7, n (%) | 121 (19%) | 93 (17%) | 28 (28%) | 0.013 |
| Glucose, mean (SD) | 135 ± 56 | 136 ± 57 | 128 ± 49 | 0.930 |
| PMH, n (%) | ||||
| AF | 137 (21%) | 107 (20%) | 30 (30%) | 0.034 |
| CAD | 147 (23%) | 118 (22%) | 29 (29%) | 0.159 |
| DM | 120 (18%) | 100 (18%) | 20 (20%) | 0.735 |
| HLP | 190 (29%) | 155 (28%) | 35 (35%) | 0.192 |
| HTN | 393 (61%) | 328 (60%) | 65 (65%) | 0.403 |
| Smoking, n (%) | 201 (31%) | 176 (32%) | 25 (25%) | 0.200 |
| Occlusion, n (%) | 221 (34%) | 158 (29%) | 63 (62%) | <0.001 |
| IA tx, n (%) | 31 (5%) | 16 (3%) | 15 (15%) | <0.001 |
| Post Fossa, n (%) | 26 (4%) | 22 (4%) | 4 (4%) | 0.782 |
| mRS, median (IQR) | 2 (0–3.2) | 1 (0–3) | 2 (1–4) | <0.001 |
| Poor outcome (mRS >2), n (%) | 253 (39%) | 202 (37%) | 51 (50%) | 0.010 |
NIHSS = NIH stroke scale score; ASPECT = admission Alberta Stroke Program Early CT score ≤7; PMH = past medical history (AF atrial fibrillation, CAD coronary artery disease, DM diabetes mellitus, HLP hyperlipidemia, HTN hypertension); occlusion = presence of major circle-of-Willis occlusion on admission CTA; IA tx = endovascular (intra-arterial) treatment; Post Fossa = posterior fossa involvement; mRS = 6-month modified Rankin score; poor outcome = 6-month mRS<2.