Table 3.

Multivariate Cox proportional hazards model

Variable	HR	95% CI	P value
Cribriform predominant
vs. Low grade	3.64	1.11–11.90	0.033
vs. Intermediate grade	1.65	0.86–3.16	0.13
vs. High grade	0.77	0.41–1.44	0.41
Sex (male vs. female)	1.53	1.10–2.14	0.012
Surgery (sublobar vs. lobar)	3.23	2.24–4.66	<0.001
Stage (IB vs. IA)	2.02	1.41–2.88	<0.001
Lymphatic invasion	1.51	1.05–2.16	0.027
Necrosis	1.96	1.32–2.92	0.001
Mitotic count
Intermediate vs. low	1.34	0.82–2.18	0.24
High vs. low	1.53	0.97–2.41	0.065

Significant p-values are shown in bold.

HR, Hazard ratio; CI, confidence interval