Table 4.

Multivariate Cox proportional hazards model

Variable	HR	95% CI	P value
Histologic subtype (vs. acinar predominant with <10% cribriform)
Low grade	0.58	0.20–1.72	0.33
Papillary	1.40	0.79–2.49	0.25
Acinar predominant with ≥10% cribriform	1.88	1.02–3.45	0.042
High grade	2.88	1.70–4.89	<0.001
Sex (male vs. female)	1.53	1.10–2.14	0.012
Surgery (sublobar vs. lobar)	3.23	2.24–4.66	<0.001
Stage (IB vs. IA)	1.97	1.38–2.80	<0.001
Lymphatic invasion	1.50	1.04–2.15	0.030
Necrosis	1.95	1.31–2.90	0.001
Mitotic count
Intermediate vs. low	1.27	0.77–2.07	0.35
High vs. low	1.46	0.93–2.31	0.10

Significant p-values are shown in bold.

HR, Hazard ratio; CI, confidence interval