Table 2.

Median [range] and p-value of percentage change in parameters between imaging timepoints (Baseline, Fraction 11 and Fraction 21)

Parameter	Baseline to Fraction 11	Baseline to Fraction 21	Fraction 11 to Fraction 21
GTV-CT	−24 [−78,−6]	−53 [−82,−27]	−23 [−53,−13]
(cm3)	p = 0.016	p = 0.016	p = 0.016
GTV-MR	−31 [−88,−3]	−70 [−92,−61]	−58 [−81,−32]
(cm3)	p = 0.008	p = 0.031	p = 0.031
GTV-DW	−53 [−77,−19]	−79 [−93,−63]	−62 [−73,−36]
(cm3)	p = 0.008	p = 0.031	p = 0.031
GTV-PET	−20 [−49,105]	−16 [−69,374]	18 [−64,132]
(cm3)	p = 0.375	p = 0.297	p = 0.578
SUVmax	−26 [−84,−18]	−60 [−78,−33]	−19 [−47,36]
	p = 0.016	p = 0.016	p = 0.219
Mean ADC value	37 [6,64]	48 [−1,105]	16 [−37,41]
(x10−3mm2s−1)	p = 0.008	p = 0.063	p = 0.563
Plasma Flow (ml/min/100 ml)	35 [15,205]	62 [35,77]	7 [4,54]
	p = 0.008	p = 0.063	p = 0.063
Plasma Volume	36 [18,155]	31 [−32,45]	−2 [−53,8]
(ml/100 ml)	p = 0.008	p = 0.313	p = 0.625
Interstitial Volume	11 [−47,165]	99 [−6,213]	37 [18,129]
(ml/100 ml)	p = 0.461	p = 0.125	p = 0.063
Permeability Surface Area Product (ml/min/100 ml)	12 [−33,240]	290 [1,481]	75 [21,360]
	p = 0.313	p = 0.063	p = 0.063
Extraction Fraction (%)	−21 [−62,150]	118 [−32,286]	55 [12,290]
	p = 0.641	p = 0.313	p = 0.063
Ktrans (min−1)	16 [−28,222]	15 [−100,422]	41 [−100,307]
	p = 0.148	p = 0.461	p = 0.742

Statistically significant results indicated in bold type.