Table 3.
Statistically significant (p < 0.05) correlations between percentage changes (Δ) in pairs of measured volumes (GTV-CT, GTV-MR, GTV-DW, GTV-PET) and functional parameters (SUVmax, mean ADC value (ADC), Plasma Flow (PF), Plasma Volume (PV), Interstitial Volume (νe), Permeability Surface Area Product (PS), Extraction Fraction (EF) and Ktrans)
| Time interval | Parameter 1 | Parameter 2 | Correlation coefficient | p-value |
|---|---|---|---|---|
| Baseline to Fraction 11 | ΔGTV-CT | ΔGTV-MR | 0.820 | 0.0239 |
| ΔGTV-CT | Δνe | −0.923 | 0.0030 | |
| ΔGTV-CT | ΔPS | −0.874 | 0.0101 | |
| ΔGTV-CT | ΔEF | −0.885 | 0.0081 | |
| ΔGTV-CT | ΔKtrans | −0.872 | 0.0105 | |
| ΔGTV-CT | ΔSUVmax | 0.910 | 0.0044 | |
| ΔGTV-MR | ΔGTV-DW | 0.785 | 0.0210 | |
| ΔGTV-MR | Δνe | −0.817 | 0.0134 | |
| ΔGTV-MR | ΔPS | −0.973 | 0.0001 | |
| ΔGTV-MR | ΔEF | −0.887 | 0.0033 | |
| ΔGTV-MR | Δ Ktrans | −0.974 | 0.0000 | |
| ΔGTV-DW | ΔPS | −0.753 | 0.0311 | |
| ΔGTV-DW | Δ Ktrans | −0.754 | 0.0306 | |
| ΔPF | ΔPV | 0.969 | 0.0001 | |
| Δνe | ΔPS | 0.914 | 0.0015 | |
| Δνe | ΔEF | 0.983 | 0.0000 | |
| Δνe | Δ Ktrans | 0.909 | 0.0018 | |
| ΔPS | ΔEF | 0.960 | 0.0002 | |
| ΔPS | Δ Ktrans | 1.000 | 0.0000 | |
| ΔEF | Δ Ktrans | 0.955 | 0.0002 | |
| Baseline to Fraction 21 | ΔGTV-CT | ΔGTV-DW | 0.851 | 0.0316 |
| ΔGTV-CT | ΔPF | 0.926 | 0.0237 | |
| ΔGTV-MR | ΔADC | 0.887 | 0.0185 | |
| ΔGTV-MR | ΔPS | −0.954 | 0.0118 | |
| ΔGTV-MR | ΔEF | −0.962 | 0.0088 | |
| ΔGTV-MR | Δ Ktrans | −0.964 | 0.0019 | |
| ΔADC | Δ Ktrans | −0.847 | 0.0334 | |
| ΔPF | Δνe | −0.936 | 0.0191 | |
| ΔPF | ΔSUVmax | 0.934 | 0.0203 | |
| ΔPS | ΔEF | 0.981 | 0.0032 | |
| ΔPS | Δ Ktrans | 1.000 | 0.0000 | |
| ΔEF | Δ Ktrans | 0.981 | 0.0030 | |
| Fraction 11 to Fraction 21 | ΔGTV-DW | ΔPF | 0.899 | 0.0381 |
| ΔPS | ΔEF | 0.972 | 0.0057 | |
| ΔPS | Δ Ktrans | 1.000 | 0.0000 | |
| ΔEF | Δ Ktrans | 0.967 | 0.0073 |