Table 7.
Details of lung cancer patients with TP53 mutations in their tumours
| Patient number | Sex | Age | Histology* | TNM | G§ | p53Abs | IHC | Exon | Codon | Nucleic acid change | Aminoacid change |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 8 | M | 70 | SCC | IB | 3 | N& | P# | 2 | 12 | c.35C > T | Pro12Leu |
| 4 | M | 70 | ADC | IB | 3 | P | P | 2 | 12 | c.35C > T | Pro12Leu |
| 54 | M | 59 | ADC | IIB | 3 | N | N | 4 | 66-81 | c.196_241del46 | Frameshift |
| 1 | M | 72 | SCC | IA | 3 | N | P | 4 | 110 | c.329G > T | Arg110Leu |
| 55 | M | 77 | SCC | IA | 3 | N | N | 5 | 152 | c.456delG | Frameshift |
| 10 | F | 55 | SCC | IIB | 3 | N | P | 5 | 154 | c.460_474del15 | Frameshift |
| 2 | M | 65 | LCC | IB | 3 | N | P | 5 | 157 | c.469G > T | Val157Phe |
| 5 | M | 41 | APC | IIB | 3 | P | P | 5 | 158 | c.473G > T | Arg158Leu |
| 3 | M | 76 | SCC | IIB | 3 | N | P | 5 | 159 | c.475G > C | Ala159Pro |
| 7 | M | 73 | SCC | IB | 2 | N | P | 5 | 167 | c.501G > T | Gln167His |
| 11 | F | 68 | ADC | IB | 2 | N | P | 6 | 199-200 | c.596_598delGAA | Frameshift |
| 56 | M | 70 | ADC | IA | 2 | N | N | 8 | 269 | c.807delC | Frameshift |
| 6 | F | 82 | ADC | IIB | 2 | P | P | 8 | 273 | c.817C > T | Arg273Cys |
| 9 | M | 50 | ADC | IB | 3 | N | P | 8 | 282 | c.844C > T | Arg282Trp |
| 12 | F | 70 | SCC | IB | 2 | N | P | 8 | 288 | c.862delA | Frameshift |
| 13 | M | 79 | SCC | IIB | 3 | N | P | 8 | 288 | c.862delA | Frameshift |
*SCC, squamous cell carcinoma; ADC, adenocarcinoma; APC, anaplastic carcinoma; LCC, large cell carcinoma. §Grade; &Low/Negative, #Positive.