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. Author manuscript; available in PMC: 2015 Dec 18.
Published in final edited form as: Cell. 2014 Dec 18;159(7):1603–1614. doi: 10.1016/j.cell.2014.11.025

Figure 2. Metabolism of co-infused [1,6-13C]glucose and [1,2-13C]acetate in GBM vs NT brain.

Figure 2

(A) 13C-NMR GBM tumor spectrum after co-infusion. Inserts are GLU4 and GLN4. Chemical shift assignments same as in Figure 1. (B) Relative percent labeling of GLU4 by acetate and glucose in 5 replicates of NT brain and T from UT-GBM1. Peak areas in GLU4 were measured from the 13C-NMR spectra. The contribution of 13C-glucose (S+D34) (blue bars) and 13C-acetate (D45+Q) (red bars) are expressed as percent of total peak area in GLU4. See also Figure S1.