Table 6.

12-month effect sizes for brain change. Mean % tissue atrophy over the interval, standard deviation (SD) of the atrophy (also in %), and n80 [with 95% confidence interval] for each of the two numerical summaries, and for both accelerated and nonaccelerated images across all 4 diagnostic groups (AD, EMCI, LMCI and CN). As expected, the change in the statistical ROI is higher than that detected in the overall temporal lobe ROI, as it focuses on voxels expected to change the most.

AD	Accel Stat ROI p<0.00001	NonAccel Stat ROI p<0.00001	Accel Temporal ROI	NonAccel Temporal ROI
% Tissue Atrophy	1.72	1.63	0.46	0.57
SD	1.20	0.99	0.78	0.65
n80 [CI]	123 [49, 445]	92 [46, 216]	710 [157, 40340]	323 [107, 3117]
LMCI	Accel Stat ROI p<0.00001	NonAccel Stat ROI p<0.00001	Accel Temporal ROI	NonAccel Temporal ROI
% Tissue Atrophy	1.29	1.41	0.45	0.43
SD	1.20	1.21	0.77	0.83
n80 [CI]	220 [119, 471]	186 [104, 391]	720 [305, 2896]	951 [335, 11061]
EMCI	Accel Stat ROI p<0.00001	NonAccel Stat ROI p<0.00001	Accel Temporal ROI	NonAccel Temporal ROI
% Tissue Atrophy	0.73	0.88	0.23	0.29
SD	0.94	1.06	0.72	0.81
n80 [CI]	420 [251, 892]	366 [222, 715]	2399 [630, 269830]	1896 [543, 88109]
CN	Accel Stat ROI p<0.00001	NonAccel Stat ROI p<0.00001	Accel Temporal ROI	NonAccel Temporal ROI
% Tissue Atrophy	0.59	0.74	0.09	0.22
SD	0.80	0.68	0.61	0.58
n80 [CI]	468 [223, 1542]	217 [126, 576]	11358 [1400, 6887100]	1768 [614, 20580]