Skip to main content
. Author manuscript; available in PMC: 2015 Nov 1.
Published in final edited form as: Nanomedicine. 2014 Jun 25;10(8):1777–1785. doi: 10.1016/j.nano.2014.06.010

Figure 1.

Figure 1

AFM schematics for force mapping of human meniscal tissue. (A) Central portion of medial meniscus was sectioned in the sagittal direction (red). The sagittal tissue portion was cut by a cryostat microtome at a thickness of 10 μm. The regions were defined by the purple line as the outer one-third, middle, and inner one-third of the tissue. (B) AFM cantilever tip with a glass microsphere attached (5 μm in diameter) was used to probe the tissue sample surface of the ECM. (C) Representative force maps (scan size of 20 μm × 20 μm) of outer, middle, and inner regions were generated from which the elastic moduli was extracted and plotted in histogram distributions.