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. Author manuscript; available in PMC: 2015 Nov 1.
Published in final edited form as: Nanomedicine. 2014 Jun 25;10(8):1777–1785. doi: 10.1016/j.nano.2014.06.010

Figure 3.

Figure 3

Nanomechanical properties of ECM of aged human meniscal tissue with OA grade 1–2. (A) Histological analyses of normal aging samples shows slight to moderate Safranin-O staining (in purple) typical of normal tissue degeneration due to aging. Scale bar = 1 mm. (B) Stiffness distribution with multi-peak Gaussian fit curves (in red) revealed both unimodal and bimodal (in green) distributions with regional variations but with a broader distribution that shifts towards stiffer values with increasing age.