Table 1.
Group (n) | Age (years) (Mean ± SEM) |
PMI (hours) (Mean ± SEM) |
Brain pH (Mean ± SEM) |
Sex (M:F) |
Suicide (n) |
DSM Axis I Diagnosis |
Blood and Brain Toxicology |
GAS (Mean ± SEM) |
N. Episodes of MDE (Mean ± SEM) |
Age of First MDE (Mean ± SEM) |
Medication Prescribed During the last 3 Months of Life |
Smoking Tobacco |
---|---|---|---|---|---|---|---|---|---|---|---|---|
C (n=18) |
46 ± 4.1 | 14.7 ± 1.2 | 6.42 ± 0.08 | 11:7 | 0 | None (18) | None (9) Anesthetics (4) Carbon Monoxide (1) |
84.3 ± 2.51 | - | - | None (18) | Yes (7) No (10) |
MD (n=17) |
51 ± 4.6 | 14.7 ± 1.8 | 6.08 ± 0.07 | 11:6 | 13 |
Primary: MDD (16) BPD (1) Comorbidity: OCD (1) GD (1) AA (1) |
None (14) Analgesic (1) |
54.4 ± 5.88 | 1.66 ± 0.32 | 44.6 ± 5.09 | None (16) Nitroglycerine (1) Atenolol (1) Albuterol (1) |
Yes (6) No (8) |
MD*ADT (n=10) |
34 ± 2.6 | 15.8 ± 2.2 | 6.39 ± 0.12 | 3:7 | 8 |
Primary: MDD (7) BPD (3) Comorbidity: CA (1) BA (2) |
Anesthetics (1) Antidepressants (Bupropion Fluoxetine Nortriptyline Paroxetine Sertraline) (10) Lithium (2) Opioids (1) Solvents (1) |
35.3 ± 7.24 | 3 ± 0.96 | 25.3 ± 2.69 | Amitriptyline (1) Benztropine Mesylate (1) Bupropion (1) Fluoxetine (3) Fluphenazine (1) Lithium (2) Nortriptyline (2) Paroxetine (1) Sertraline (2) Trazodone (3) Valproic Acid (1) |
Yes (3) No (7) |
MD*ADT*BZD (n=7) |
57 ± 6.8 | 16.9 ± 4.3 | 6.57 ± 0.18 | 4:3 | 4 |
Primary: MDD (4) BPD (3) |
Analgesic (2) Antidepressants (7) Antipsychotics (1) Barbiturates (2) BZD (7) Fluoxetine (1) Mianserin (1) Opioids (2) Sertraline (2) |
11.2 ± 7.14 | 1 | 68.7 ± 7.66 | Sertraline (1) Clomipramine (1) |
Yes (1) No (3) |
AA = Alcohol Abuse; BA = Bulimia/ Anorexia; BPD = Bipolar Disorder; BZD = Benzodiazepines; C = controls without psychopathology or treatment; CA = Cannabis Abuse; GAS = Global Assessment Scale; GD = Gambling Disorder; MDD = Major Depressive Disorder; MD = Untreated subjects with mood disorder; MD*ADT = Subjects with mood disorder treated with antidepressant only; MD*ADT*BZD = Subjects with mood disorder treated with antidepressants and benzodiazepines; OCD = Obsessive Compulsive Disorder; SEM = standard error of the mean.